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...t their function in the non‐chamber myocardium shown in gray ... Unveiling the mechanism of cardiac pacemaker development ... ... . The Tbx2(+) Primary Myocardium of the Atrioventricular Canal Forms the Atrioventricular Node and the Base of the Left Ventricle June 2009 Circulation Research 104(11):1267-74 Wnt Signaling Regulates Atrioventricular Canal Formation Upstream of BMP and Tbx2 Article in Birth Defects Research Part A Clinical and Molecular Teratology 91(6):435-40 · June 2011 with 113 Reads Request PDF | Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: impl ... Development of the Cardiac Conduction System | Circulation ... ... .5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation | During heart development, chamber myocardium ... Tbx2 has been implicated in the regulation of the cell cycle and senescence in various cell types, including fibroblasts and certain tumors. 33 A role of Tbx2 in regulation of proliferation in the heart was not observed. 18 We defined regional proliferation in the E9.5 mouse heart using quantitative 3D reconstruction of 5-bromodeoxyuridine (BrdUrd)-labeling indices. 34 In wild-type embryos, we ... Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outﬂow tract during heart development Zachary Harrelson 1 , Robert G. Kelly 1 , Sarah N. Goldin, Jeremy J. Gibson-Brown 1,2,3 , Roni J. Bollag 3,4 , The first step of cardiac conduction is impulse generation. The sinoatrial (SA) node (also referred to as the pacemaker of the heart) contracts, generating nerve impulses that travel throughout the heart wall.This causes both atria to contract. The SA node is located in the upper wall of the right atrium. T-box factors Tbx2 and Tbx3 play key roles in the development of the cardiac conduction system, atrioventricular canal, and outflow tract of the heart. They regulate the gap-junction-encoding gene Connexin43 (Cx43) and other genes critical for heart development and function. Discovering protein partners of Tbx2...